A 60-year-old woman is suspected of having non-Hodgkin lymphoma (NHL). Which of the following aspects of her condition would help to rule out Hodgkin lymphoma?
A. The lymph nodes involved are located in a large number of locations in the lymphatic system.
B. The woman complains of recent debilitating fatigue.
C. Her neoplasm originates in secondary lymphoid structures.
D. The presence of Reed-Sternberg cells has been confirmed.